Novel role for retinol-binding protein 4 in the regulation of blood pressure
نویسندگان
چکیده
منابع مشابه
Regulation of retinol‐binding protein 4 and retinol metabolism in fatty liver disease
Vitamin A refers to a spectrum of retinoid compounds (retinol, retinoic acid, and retinaldehyde) with important functions in different tissues, including the retina and skin. Retinoids regulate metabolic pathways through binding to two nuclear hormone receptors: retinoic acid receptor and retinoid X receptor. In humans, approximately 80% of the body reservoir of vitamin A is stored in the liver...
متن کاملMacrophages are novel sites of expression and regulation of retinol binding protein-4 (RBP4).
Obesity is linked to a low-level chronic inflammatory state that may contribute to the development of associated metabolic complications. Retinol-binding protein 4 (RBP4) is an adipokine associated with parameters of obesity including insulin resistance indices, body mass index, waist circumference, lipid profile, and recently, with circulating inflammatory factors. Due to the infiltration of a...
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OBJECTIVE Retinol-binding protein (RBP) 4 is an adipokine of which plasma levels are elevated in obesity and type 2 diabetes. The aims of the study were to identify determinants of plasma RBP4 and RBP4 mRNA expression in subcutaneous adipose tissue (SAT) and skeletal muscle and to investigate the association between RBP4 and in vivo measures of glucose metabolism. RESEARCH DESIGN AND METHODS ...
متن کاملRetinol-binding protein 4 in human obesity.
Studies in mice suggest that adipocytes serve as glucose sensors and regulate systemic glucose metabolism through release of serum retinol-binding protein 4 (RBP4). This model has not been validated in humans. RBP4 was highly expressed in isolated mature human adipocytes and secreted by differentiating human adipocytes. In contrast to the animal data, RBP4 mRNA was downregulated in subcutaneous...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2015
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.14-266064